To evaluate CNS depression, anxiolytic and anti-epileptic activity of methanolic extract of Luffa echinata Roxb. Fruit in experimental animals. CNS depression activity of mehanolic extract of Luffa echinata (MELE)(20mg/kg, p.o.) was measured using Open field behavior model and anxiolytic activity was performed using Elevated plus maze model using diazepam (2mg/kg, p.o.) as a reference standard in both the models. Anti-epileptic activity of MELE (20mg/kg, p.o.) was performed using Maximal Electric Shock (MES) model using phenytoin (25mg/kg, p.o.) as a reference standard. In open field model MELE showed significant reduction in number of square crossed (7.75±0.85) and number of rearing (1.00±0.70) as compared to control (81.00±26.35, 14.50±2.22) (p< 0.05). In elevated plus maze model MELE showed significant increased in time spent in open arm (136.25±17.96) as compared to control (65.25±7.09). In MES model, MELE showed significant decreased in extension, stupor and total recovery as compared to control. Methanolic extract of Luffa echinata Roxb. Fruit showed significant CNS depression, anxiolytic and anti-epileptic activity in experimental animals.
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